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Typical microscopic changes in muscle tissue of someone with Duchenne's muscular dystrophy?
Wiki User
∙ 10y ago
Microscopic examination of the affected muscle would show the following changes:
A. degenerating skeletal muscle fibers (i.e. "cells").
B. proliferation of endomysium connective tissue around the degenerating muscle cells.
C. numerous macrophages (i.e. scavenger white blood cells) in the area, whose job it is to clear the cellular debris in the damaged muscle tissue.
D. while some of the muscle fibers are breaking down (as seen in a cross section), other fibers appear to be dense (or dark in color). These latter cells are presumably in a state of excessive contraction (i.e. more overlap between actin and myosin), probably because other segments of these cells (not in the microscopic viewing field) are experiencing breakdown of the cell membrane. Destruction of the cell membrane would of course, allow calcium ions to flow into the cell from the extracellular fluid (down their electrochemical gradient). As calcium floods the interior of these cells, it binds to troponin and causes a shift in tropomyosin, thus exposing the globular head binding sites on actin. Cross-bridges form and, in the muscle cell's "last breath," it contracts.
Wiki User
∙ 10y ago
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