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Yes, she originally tried to join an order of nuns at age 18, but poor health prevented her taking the veil. A priest asked her to teach at a girl's school, the House of Providence Orphanage in Cadagono, Italy, which she did for six years. She took religious vows in 1877, and did so well at her work that when the orphanage closed in 1880, her bishop asked her to found the Missionary Sisters of the Sacred Heart to care for poor children in schools and hospitals. Pope Leo XIII then sent her to the United States to carry on this mission.

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