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The major conflict in South Carolina was the Yamasee war of 1715 to 1717, between colonists and militia on one side and someelements of the Yamasee, Muscogee, Cherokee, Chickasaw, Catawba, Apalachee, Apalachicola, Yuchi, Savannah River Shawnee, Congaree, Waxhaw, Pee Dee, Cape Fear, Cheraw, and other tribes on the other.

In 1715 the future of the colony was in serious doubt due to the number of settlers killed, but the Cherokee changed sides in 1716 to aid the settlers. This brought about a complete reversal and gradually the "hostiles" withdrew from the war, leaving the area in peace.

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Q: Was there a war in South Carolina with native tribes?
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