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The first known artificial refrigeration was demonstrated by William Cullen at the University of Glasgow in 1748. The American inventor Oliver Evans, acclaimed as the "father of refrigeration," invented the vapor-compression refrigeration machine in 1805. Heat was removed from the environment by recycling vaporized refrigerant, where it moved through a compressor and condenser, where it eventually reverted to a liquid form to repeat the process. However, Evans built no such refrigeration unit.In 1834, Jacob Perkins modified Evans' original design, building the world's first refrigerator and filing the first legal patent for refrigeration using vapor-compression. John Gorrie, an American doctor from Florida, invented the first mechanical refrigeration unit in 1841-based on Evans' original invention to make ice in-to cool air for yellow fever patients. Gorrie's mechanical refrigeration unit received a patent in 1851. American professor Alexander C. Twining of Cleveland, Ohio patented an early vapor-compression refrigerator in 1853 that was fully capable of producing a ton of ice per day.

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