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Proteins that are synthesized in the ER are transported out of the cell after certain modifications in the Golgi by the path known as the secretary pathway.

Proteins that are synthesized in the ER are transported out of the cell after certain modifications in the Golgi by the path known as the secretary pathway.Usually, the protiens posses signals on their exposed chains which helps the golgi sort it and transport the protein to it's destination, for instance, proteins that belong to the nucleus have a nuclear localization signal (NLS) consisting of a sequence rich in basic amino acids. Similarly, proteins that belong to the peroxisome has a mannose-6-phosphate group attached, but the proteins that belong to the extracellular matrix do not have a particular signal on them; even if they do have, the trans Golgi network does not recognize it.

Usually, the protiens posses signals on their exposed chains which helps the golgi sort it and transport the protein to it's destination, for instance, proteins that belong to the nucleus have a nuclear localization signal (NLS) consisting of a sequence rich in basic amino acids. Similarly, proteins that belong to the peroxisome has a mannose-6-phosphate group attached, but the proteins that belong to the extracellular matrix do not have a particular signal on them; even if they do have, the trans Golgi network does not recognize it.Usually, the protiens posses signals on their exposed chains which helps the golgi sort it and transport the protein to it's destination, for instance, proteins that belong to the nucleus have a nuclear localization signal (NLS) consisting of a sequence rich in basic amino acids. Similarly, proteins that belong to the peroxisome has a mannose-6-phosphate group attached, but the proteins that belong to the extracellular matrix do not have a particular signal on them; even if they do have, the trans Golgi network does not recognize it.

Proteins that are synthesized in the ER are transported out of the cell after certain modifications in the Golgi by the path known as the secretary pathway.Usually, the protiens posses signals on their exposed chains which helps the golgi sort it and transport the protein to it's destination, for instance, proteins that belong to the nucleus have a nuclear localization signal (NLS) consisting of a sequence rich in basic amino acids. Similarly, proteins that belong to the peroxisome has a mannose-6-phosphate group attached, but the proteins that belong to the extracellular matrix do not have a particular signal on them; even if they do have, the trans Golgi network does not recognize it.Therefore, such proteins are packed in vessicles coated with clathrin and are moved on the molecular motors (kinesin) towards the plasma membrane, where the vessicle fuses and releases the protein outside.

Therefore, such proteins are packed in vessicles coated with clathrin and are moved on the molecular motors (kinesin) towards the plasma membrane, where the vessicle fuses and releases the protein outside.Therefore, such proteins are packed in vessicles coated with clathrin and are moved on the molecular motors (kinesin) towards the plasma membrane, where the vessicle fuses and releases the protein outside.

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