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The risk of deformity or Down syndrome in a baby conceived by a brother and sister (consanguineous relationship) is higher compared to unrelated parents. This is due to the increased likelihood of sharing similar genetic mutations, which can increase the risk of genetic disorders.

The risks include:

  1. Autosomal recessive disorders (e.g., cystic fibrosis, sickle cell anemia)

  2. Autosomal dominant disorders (e.g., achondroplasia, Huntington's disease)

  3. Chromosomal abnormalities (e.g., Down syndrome, Turner syndrome)

  4. Congenital anomalies (e.g., heart defects, cleft palate)

The exact risk depends on the degree of consanguinity (how closely related the parents are) and the specific genetic disorders in the family.

For first cousins (once removed), the risk of birth defects is around 4-6%. For full siblings (brother and sister), the risk is higher, around 10-15%.

It's important to note that the majority of children born to consanguineous parents are healthy, and many genetic disorders can occur in unrelated parents as well.

If you have concerns, consult a genetic counselor or a medical professional for personalized advice.

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Meena Khans

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1y ago

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