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Hemolytic anemias are conditions in which the blood is low in oxygen because the red blood cells are breaking down at a faster rate than their normal life expectancy of 120 days.
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What are inherited hemolytic anemias caused by?
Inherited hemolytic anemias are caused by inborn defects in components of the red blood cells--the cell membrane, the enzymes, or the hemoglobin
What are acquired hemolytic anemias caused by?
Acquired hemolytic anemias are those that result from various other causes. With this type, red cells are produced normally, but are prematurely destroyed
What is pyruvate kinase?
Pyruvate kinase deficiency (PKD) is part of a group of disorders called hereditary nonspherocytic hemolytic anemias.
What is the prognosis for hemolytic anemia?
In about 15% of cases, the baby is severely affected and dies before birth. Babies who survive pregnancy may develop kernicterus, which can lead to deafness, speech problems, cerebral palsy, or mental retardation.
What are some diseases of the circulatory and immune systems?
Diseases that affect both the immune system and circulatory system include temporal arteritis and other autoimmune vasculitides, immune-modulated hemolytic anemias, and lupus-related heart disease, for a few examples.
Who is most likely to get pyruvate kinase deficiency?
Caucasians of northern and central European decent are more likely to have the 1529A mutations, individuals of southern European descent usually have the 1456T mutation,
Can clozapine cause hemolytic anemia?
Hemolytic anemia indicates the early destruction of red blood cells. This can occur as inherited or acquired hemolytic anemia. Certain medicines can cause acquired hemolytic anemia, please check with the doctor.
What are the indication of indirect coombs test?
A Coomb's test will indicate the formation of antibodies on the red blood cell. This test can be used to determine blood type, and diagnose certain hemolytic anemias. A Coombs' test may also indicate the prescense of maternal antibodies against the fetal blood type as occurs in erythroblastosis fetalis.
Hemolytic anemia caused by chemicals and toxins?
DefinitionHemolytic anemiacaused by chemicals and toxins is a lack of enough red blood cells due to the destruction of red blood cells triggered by exposure to certain chemicals or toxins.Alternative NamesAnemia - hemolytic - caused by chemicals or toxinsCauses, incidence, and risk factorsPossible substances that can cause hemolytic anemia include:Anti-malaria drugs (quinine compounds)ArsenicDapsoneIntravenouswater infusion (not half-normal saline or normal saline)Metals (chromium/chromates, platinum salts, nickel compounds, copper, lead, cis-platinum)NitritesNitrofurantoinPhenazopyridine (Pyridium)Rho immune globulin (WinRho)RibavirinSnake bites(some snake venom contains hemolytic toxins)SulfonamidesSulfonesReferencesSchwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 164.Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 48.
What is xanthocytes?
Xanthocytes are red blood cells that have an abnormal shape, often due to lipid accumulation in the cell membrane. They can be seen in conditions such as liver disease, obstructive jaundice, or hemolytic anemias. Their presence on a blood smear can provide important diagnostic information.
What has a hemolytic function?
spleen
What conditions are present when hemolytic disease of the newborn occurs?
Hemolytic disease of the newborn is known as erythroblastosis fetalis
