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  1. Take Florida's Turnpike (toll road) NORTH to I-75 NORTH.
  2. Take I-75 NORTH to I-24 WEST to CHATTANOOGA and Nashville at EXIT 2 in Tennessee near Chattanooga. You can bypass Macon, Georgia by taking I-475 (EXIT 156 off I-75) and you can also bypass Atlanta, Georgia by taking I-285 WEST BYPASS (EXIT 238B off I-75, then EXIT 20 off I-285 to get back onto I-75 NORTH).
  3. Take I-24 WEST through Nashville and Tennessee, and Kentucky to I-57 NORTH to CHICAGO at EXIT 44B in Illinois.
  4. Take I-57 NORTH to I-64 WEST to St. Louis at EXIT 96.
  5. Take I-64 WEST to St. Louis.
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Q: What are driving directions to St. Louis from orlando?
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