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What are some methods used to enhance the solubility of poorly soluble drugs?
Wiki User
∙ 16y ago
If talking about solubility in water, convert diclofenac into its sodium salt. Solubility increases by ~ 2 orders of magnitude. If your solvent doesn't have to be water, use alcohol (ethanol is best) or propylene glycol.
Wiki User
∙ 15y ago
Wiki User
∙ 16y agoAcidifying it into a salt, or freebaseing it with a base, depending on it's qualities, heat helps, and using a differant solvent such as alcohol or oil can help too.
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Need more info. AgCl, however, is very poorly soluble.
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Need more info. AgCl, however, is very poorly soluble.
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