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  1. Take US-45 NORTH to US-72 EXIT.
  2. Turn right off the exit ramp onto US-72 EAST.
  3. Continue straight on US-72 EAST through Mississippi and Alabama to I-24 EAST in Tennessee.
  4. Take I-24 EAST to Chattanooga.
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Q: What are the best driving directions from Tupelo Mississippi to Chattanooga Tennessee?
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