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Injury causes damaged tissue cells to produce prothrombin activator. This, along with a clotting factor produced by the sticky platelets (cell fragments) at the damaged site, cause prothrombin + calcium to make thrombin (blood protein). All the while fibrinogen is stimulated to make fibrin (blood protein). The fibrin ensnares RBCs to form the clot with the platelets.

All factors have to be there for the clotting to occur. Lack of any of them causes bleeding disorders.

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Q: What are the blood clotting factors plasma proteins and cells fragment called?
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