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VHL causes tumors in the organs. im 13 years old and me and my mom have i t my mom has had surgey for because it was in her kiddney.

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Q: What are the causes of vhl?
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What causes Von Hippel-Lindau disease?

Mutations in the VHL gene on chromosome 3 are now known to cause the condition. VHL is inherited in an autosomal dominant manner.


What cause von hippel lindau?

Mutations in the VHL gene on chromosome 3 are now known to cause the condition. VHL is inherited in an autosomal dominant manner.


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What is the prognosis for people with Von Hippel-Lindau disease?

Those people who die may do so as a result of significant complications with tumors. Renal cell carcinomas and CNS hemangioblastomas have been the greatest causes for death in people with VHL.


How does angiogenesis work?

In low oxygen gene regulatory protein called HIF-1 stimulates the transcription of the VEGF gene, the Vascular endothelial growth factor. This causes the endothelial cells to use proteases to digest there way through and bring new blood to the cells. This can also happen in cancers cells and this how cancer tumors can become vascularized. In a disorder called VHL - Von hippel-lindau. They are only born with one functioning copy of the VHL gene, mutations occur and they get random cancer throughout there body.


What is the genetic disorder?

Von Hippel-Lindau disease (VHL) is an extremely rare genetic condition. It is said to affect 1 in 35,000 people.


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What is involved in Von Hippel-Lindau disease?

VHL often involves symptoms in the central nervous system (CNS) and include hemangioblastomas of the cerebellum , spinal cord, brain stem, and nerve root.


What conditions cause inherited pheochromocytomas?

Multiple Endocrine Neoplasia, type 2A (MEN2A), Multiple Endocrine Neoplasia, type 2B (MEN2B), von Hippel-Lindau disease (VHL) and Neurofibromatosis type 1 (NF1).


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