I'm not a dentist but I am a doctor. I've had to use Alvogyl recently with more than one application for a long standing dry socket. I've asked numerous dentists and searched the internet for this answer. It seems that there are no known significant side effects except the possibility of delaying the overgrowth of new tissue over the dry socket to cover the exposed bone. It should therefore not be packed tightly in the socket - just enough to fill the space loosely. Hope this helps.