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(Don't know if these are right for sure...) South Carolina and West Virginia...
Some major cities include Charleston, Knoxville, and Asheville.
Major cities in South Carolina include Columbia, Charleston and Mount Pleasant. Other highly populated cities are Greenville, Goose Creek, and Sumter.
Tokyo, Japan; Seoul, South Korea; and Cairo, Egypt are major cities in the eastern hemisphere. Other major cities in the eastern hemisphere include London, England; Paris, France; Rome, Italy; and Berlin, Germany.
The top then largest cities in the state are (in order from largest to smallest) Charleston, Huntington, Parkersburg, Wheeling, Morgantown, Weirton, Fairmont, Beckley, Clarksburg, and Martinsburg.
Charleston, South Carolina
By 1840 there were nearly 4 million slaves in the southern states. One of the major cities was New Orleans and Charleston had a huge slave market.
Strasbourg and Mulhouse are the largest cities in Alsace, eastern France.
There are 2 major US cities named Charleston. One is the capital of West Virginia. The other is a major port in South Carolina.
There are no cities, states, or countries on the Antarctic continent.
The distance between the two cities' major airports is about 805 air miles.
The anagram is Charleston, the name of major cities in South Carolina and West Virginia.