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Kuntz and keller type

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Was thalidomide man-made?

THE FIRST CONTRIBUTOR ARGUED: Thalidomide was man-made by the two inventors called Dr.W.Kunz and Dr.H.Keller. This appalling drug was made in Germany. THIS CONTRIBUTOR CALLS HIMSELF THE SECOND CONTRIBUTOR AND REPLIES: A distinction should be made between the thalidomide drug and the thalidomide scandal. Yes, the thalidomide DRUG was man-made But not necessarily in Germany. It may have been made in the United States of America, France or even the United Kingdom of Northern Ireland and Great Britain. (1) The thalidomide SCANDAL was however government-made. BEFORE 10 APRIL 2010, THE SECOND CONTRIBUTOR KNEW THAT The regulators allowed thalidomide on the market in 1957. At a 30 April - 1 May 1960 Düsseldorf Congress of neurologists, neurologist Dr Ralf Voss warned that thalidomide attacks the nervous system of the mother. The regulators did not do anything and it was up to the manufacturer of thalidomide, Chemie Grünenthal in Stolberg, Aachen, to withdraw thalidomide from the market on 27 November 1961, that's eighteen months after the warning that thalidomide attacks the nervous system of the mother. (2) ON 10 APRIL 2010 On 10 April 2010, the French daily Le Monde reported that thalidomide was withdrawn in December 1961 and that two years before that date, many German doctors warned that thalidomide attacked the nervous system of the mother. (3) This would mean that the thalidomide alarm was raised in December 1959. And the regulators let it on the market until December 1961. That's twenty-four months, right? THE STORY GOES The story goes that a young Canadian-born doctor, named Frances Oldham Kelsey, managed to convince the USA Food and Drug Administration (FDA) not to allow thalidomide, known in the USA as "kevadon", into the USA. The problem with this story is that Kelsey was only appointed to the FDA in 1960 (4) and that, oh wonder, the first drug she had to examine at the FDA was ... kevadon. That examination of thalidomide by FDA bureaucrat Kelsey started on 12 September 1960 (4 and 5). That examination thus started after the 30 April - 1 May 1960 Düsseldorf warning. (And the real thalidomide warning was in December 1959, says Le Monde.) THE STORY THEN CONTINUES Dr. Frances Kelsey, then a medical officer with the fledgling Food and Drug Administration, [...] shows immense courage by staunchly refusing to grant permission for the release of the medication in the United States. She does so despite enormous pressure both from her superiors and the American pharmaceutical company that has MILLIONS OF THALIDOMIDE TABLETS READY FOR MASS DISTRIBUTION. But for her, a calamity of unprecedented magnitude, a consequence of, " …gigantic marketing plans…" and an "…absence of scientific discipline…" would have been inevitable. [capitalisation by the second contributor.] (6) The second contributor asks: Did the so-called regulators in the countries where thalidomide had been allowed also have millions of thalidomide tablets ready for mass distribution and does that explain why these so-called regulators NEVER reacted to the December 1959 warning, by removing thalidomide from the market, but let the heroes from Chemie Grünenthal in Stolberg, Aachen take the initiative of that withdrawal in December 1961? CONCLUSION The thalidomide scandal was made by guv'mints to justify or legitimate their welfare states. Or was the drug really woman-made in 1938 by Frances Oldham Kelsey? (7) No distinction should then be made between the thalidomide drug and the thalidomide scandal?


Was thalidomide man made?

THE FIRST CONTRIBUTOR ARGUED: Thalidomide was man-made by the two inventors called Dr.W.Kunz and Dr.H.Keller. This appalling drug was made in Germany. THIS CONTRIBUTOR CALLS HIMSELF THE SECOND CONTRIBUTOR AND REPLIES: A distinction should be made between the thalidomide drug and the thalidomide scandal. Yes, the thalidomide DRUG was man-made But not necessarily in Germany. It may have been made in the United States of America, France or even the United Kingdom of Northern Ireland and Great Britain. (1) The thalidomide SCANDAL was however government-made. BEFORE 10 APRIL 2010, THE SECOND CONTRIBUTOR KNEW THAT The regulators allowed thalidomide on the market in 1957. At a 30 April - 1 May 1960 Düsseldorf Congress of neurologists, neurologist Dr Ralf Voss warned that thalidomide attacks the nervous system of the mother. The regulators did not do anything and it was up to the manufacturer of thalidomide, Chemie Grünenthal in Stolberg, Aachen, to withdraw thalidomide from the market on 27 November 1961, that's eighteen months after the warning that thalidomide attacks the nervous system of the mother. (2) ON 10 APRIL 2010 On 10 April 2010, the French daily Le Monde reported that thalidomide was withdrawn in December 1961 and that two years before that date, many German doctors warned that thalidomide attacked the nervous system of the mother. (3) This would mean that the thalidomide alarm was raised in December 1959. And the regulators let it on the market until December 1961. That's twenty-four months, right? THE STORY GOES The story goes that a young Canadian-born doctor, named Frances Oldham Kelsey, managed to convince the USA Food and Drug Administration (FDA) not to allow thalidomide, known in the USA as "kevadon", into the USA. The problem with this story is that Kelsey was only appointed to the FDA in 1960 (4) and that, oh wonder, the first drug she had to examine at the FDA was ... kevadon. That examination of thalidomide by FDA bureaucrat Kelsey started on 12 September 1960 (4 and 5). That examination thus started after the 30 April - 1 May 1960 Düsseldorf warning. (And the real thalidomide warning was in December 1959, says Le Monde.) THE STORY THEN CONTINUES Dr. Frances Kelsey, then a medical officer with the fledgling Food and Drug Administration, [...] shows immense courage by staunchly refusing to grant permission for the release of the medication in the United States. She does so despite enormous pressure both from her superiors and the American pharmaceutical company that has MILLIONS OF THALIDOMIDE TABLETS READY FOR MASS DISTRIBUTION. But for her, a calamity of unprecedented magnitude, a consequence of, " …gigantic marketing plans…" and an "…absence of scientific discipline…" would have been inevitable. [capitalisation by the second contributor.] (6) The second contributor asks: Did the so-called regulators in the countries where thalidomide had been allowed also have millions of thalidomide tablets ready for mass distribution and does that explain why these so-called regulators NEVER reacted to the December 1959 warning, by removing thalidomide from the market, but let the heroes from Chemie Grünenthal in Stolberg, Aachen take the initiative of that withdrawal in December 1961? CONCLUSION The thalidomide scandal was made by guv'mints to justify or legitimate their welfare states. Or was the drug really woman-made in 1938 by Frances Oldham Kelsey? (7) No distinction should then be made between the thalidomide drug and the thalidomide scandal?


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If Thalidomide use was stopped in 1961 why were my little brother and another girl I know both born in the US in late 1963 with identical genital and visual thalidomide birth defects?

Thalidomide was never approved for use in the United States. NEVER! So, first, one must determine if the two individuals you mentioned have been officially diagnosed by a physician as having genital and visual birth defects that are caused ONLY BY THALIDOMIDE and (a) not caused by another medication or (b) not congenital in nature.Second, if congenital birth defects and other medications have been ruled out as causative, then one must remember that, simply because a medication is no longer being manufactured or dispensed, it continues to be available for an unknown period of time in the homes of those for whom it was prescribed or who purchased it prior to the date when sales and manufacturing ceased.Therefore, IF the birth defects have been definitively identified as being related to Thalidomide, then the mother of each child must have had access to Thalidomide via her own individual supply or from the supply of someone else.To further complicate matters, Thalidomide was ALSO USED IN COMBINATION with other medications to treat conditions such as migraine and asthma, making it much less likely that someone who was using such a combination product would be AWARE of the potential danger.In all cases, the medication would have originated from a country other than the United States because, as already noted, no Thalidomide products were ever approved for sale in the United States.In summary, in 1961, the manufacturing, dispensing, and sale of Thalidomide and Thalidomide-containing combination products was stopped. The USE of these products continued because of the medication that was already in the hands of the public.Regrettably, any continued use may have been partly attributable to the public not having been fully educated in 1961 regarding the risks of Thalidomide and Thalidomide-containing combination products. This is especially true for U.S. citizens who may have received one of these products when traveling outside of the United States.


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Why is thalidomide still available today?

THE FIRST CONTRIBUTOR ARGUED: Thalidomide has legitimate medical uses. For example, it can be used to treat [Hansen]'s disease (used to be called leprosy) and multiple myeloma. The risk vs reward ratio for all drugs must be carefully evaluated. The risk for pregnant women taking thalidomide for morning sickness clearly outweighs any possible benefit that the woman might receive through the mitigation of her morning sickness. So those women taking thalidomide for other treatment must take every precaution against becoming pregnant. But this is no different than other drugs that are demonstrated teratogens, such as Acutane, which is prescribed for the control of serious acne THIS CONTRIBUTOR CALLS HIMSELF THE SECOND CONTRIBUTOR AND REPLIES: Every mother knows that her child should not play with a toy the child does not understand. The mechanism of the biological action of thalidomide is still being debated. Human nature is constituted as such that some individuals who have inside knowledge about the effects of thalidomide will 'always' deliberately and unnoticeably cause the serious harm thalidomide can 'so easily' cause. They do that precisely because the damage is so serious to the mother and to the child and because they can do that so easily and without being noticed. It may be that 'in clinical trials', thalidomide is shown to be effective against many things. But 'in real life', it is given to unsuspecting girls. TWO REMAINING PUZZLES (for the second contributor): ONE Thalidomide is a cure against Hansen's disease, leprosy. The second contributor is no medical doctor, but his understanding of leprosy is that it "takes" limbs "away". (1) The effect of thalidomide on foetuses is thus similar to the symptoms of leprosy on human beings. Still, thalidomide is cure of/against leprosy. Since Aristotle, the principle of non-contradiction (the PNC) says that it is impossible to be and not to be at the same time and in the same respect. Contrary to what many authors argue, this principle, or law, is not applicable to reality, only to thought. (2) Thought is submitted to the PNC. Reality is not. How can the thought of the advocates of the use of thalidomide get away with the apparent contradiction that thalidomide is both the cause of and the cure of leprosy(-like symptoms)? Is it being argued that using thalidomide on pregnant women and using it on non-pregnant people suffering of leprosy is using it in a different respect? Multiple myeloma, say the ophthalmologists? TWO Thalidomide attacked the embryo, not the infant. It attacked the sensory, not the motor "nerves". (3) It thus did not act on the limb bud. Indeed, thalidomide caused upper limb deformities by action before the limb had existed. (4) The damaging drug may have been developed by the Nazis as an antidote to "nerve" gas. (5) Again, the second contributor is no medical doctor, but he's surprised by the double occurrence of the same noun "nerve". THE ULTIMATE PUZZLE: Why is thalidomide still available today? NOTES (1) Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Leprosy does not directly cause body parts to fall off on their own accord; instead they become disfigured or autoamputated as a result of disease symptoms. http://en.wikipedia.org/wiki/Leprosy (2) Fernand Van Steenberghen, (F.-X. de Guibert, ed.), Philosophie fondamentale , Longueuil, Québec, Editions du Préambule, 1989, footnote p. 296: Contrairement à ce qu'affirment beaucoup d'auteurs, ces principes [the principle of non-contradiction, the law of the excluded-middle and the law of identity] sont des Lois logiques ou des Lois de pensée comme telle et non des Lois de l'ordre réel. (3) Janet McCredie, "Beyond Thalidomide - Birth Defects Explained", London, The Royal Society of Medicine Press, 2007, p. 405 (4) McCredie, p. 152 (5) From The Sunday Times February 8, 2009 Thalidomide 'was created by the Nazis' The damaging drug may have been developed as an antidote to nerve gas Daniel Foggo http://www.timesonline.co.UK/tol/life_and_style/health/article5683577.ece


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