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Q: What are the two models that illustrate the binding of the substrate to the enzyme?
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Choose two of the models that illustrate the stages of grief fellowing bereavement and compare their features to identify the similarities and differences?

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What types of binding machines are available at Office Depot?

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When was the spiral binding machine developed?

in France - approximately in 1940. see http://www.bindingstuff.net/combbinding.html for current models of comb binding equipment


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Fellowes makes the full spectrum of binding machines from plastic comb binding machines to the professional thermal models. The plastic comb binding machines can be bought for about $100. The thermal binding machines sell for $500 and up.


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What factors affect the rate at which an enzyme works?

Very basically: * specificity - the better 'fit' the substrate, the higher the rate of catalysis. * temperature - higher temp = more kinetic energy = faster eaction. However, too high and the enzyme becomes irreversibly denatured and will not work at all. (denatured = the folding of the peptide chains are disrupted, meaning that the shape changes and the substrates no longer fit). The temperature at which the reaction occurs at the fastest rate is called the optimum temperature. * pH - enzymes have specific pH that they work best at (the optimum/optimal pH), as pH can also affect the bonds holding the tertiary structure together (especially ionic bonds), denaturing the enzyme. * concentration of enzyme and substrate - rate of reaction is proportional to the enzyme/substrate concentration. However, at a given enzyme concentration, substrate conc is proprtional to rate up to a point when the enzyme becomes saturated and the rate remains constant. * cofactors/coenzymes - some enzymes require interaction with other molecules to show full catalytic activity. * inhibitors - the presence of an inhibitor lowers the rate of catalysis. There are competitive, uncompetitive, non-competitive and mixed inhibitors, they can bind reversibly or irreversibly, at the active site or an allosteric site... That's a very simple, school textbook answer (and I may have forgotten a factor?). For more detail, any biochemistry textbook should be able to help.


The function of models in science?

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The problem with our current models is that there is not enough data to allow us to determine which of the popular models are best. A model may come to be accepted if new data supports it, while at the same time contradicting other models.


What has the author Jean Pierre Kernevez written?

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