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Thermoplastics can be melted into liquids using heat and then set again when they cool. This is often useful for recycling and such. Melt it down, make something else.

Thermosetting polymers cannot be melted down in such a way and will generally just burn if you try to heat them too much. It's quite common for thermosetting polymers to start off as a liquid and then be "cured" to become hard...often using heat. Once they have been cured, they cannot be reverted back to a liquid. This sounds disadvantageous but thermosetting polymers are usually much tougher than thermoplastics, so you just pick the right one for the job.

Like tyres, for example...you can't have them melting when they get hot, and they need to be tough so thermosetting polymers are a good idea.

A final note about thermoplastics: if you lower the temperature (usually it has to be a lot - there's a really cool balloon + liquid nitrogen experiment you can do for this) they will become a sort of glass, but will revert back when warmed through.

The two are very different in terms of packing. I'm sure there is some overlap but generally speaking, thermoplastics tend to polymerise in long chains that then pack together. Thermosetting polymers take on a more permanent 3D structure.

There's a lot to say about them, but those are some major bullet points. Search Google for further reading, or ask a more specific question if one is needed.

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