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The only barbiturate currently used to treat headaches (tension, migraine, or cluster headaches) is butalibital.

It comes in the following forms:

Fioricet (butalbital, acetaminophen, caffeine)

Fiorinal (butalbital, aspirin, caffeine)

Fioricet w/ codeine (butalbital, acetaminophen, caffeine, codeine)

In the 60's and 70's, barbiturates were prescribed more commonly to treat a number of things. With the invention of things like the triptans (eg, Imitrex) for migraine and benzodiazepines (eg, Ativan, Xanax) for anxiety and many, many anti-seizure medications, barbiturates have been mostly phased out, quite a lot of them not being made any more.

The blends of butalbital listed above have actually been phased out in many countries. It has been shown to do more harm than good and has a higher probability than many other compound medications (like Percocet or Excedrin) at causing transformed migraine due to medication overuse.

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Q: What barbiturates treat headaches?
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