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Elevated LDH levels can mean that you:(a) are experiencing hemolysis or the breakdown of red blood cells in your body tissues which contain LDH(b) if your levels remain high for up for several days, it could mean a myocardial infarction (heart attack) is on the way.(c) If your blood sample was incorrectly handled, the results may show that you have high levels of LDH even if you don't. This may be due to erythrocyte damage.(d) High levels of LDH may also indicate the presence of cancer cells, which destroy red blood cells found in your body tissues and release LDH into the blood stream.(e) In empyema, the LDH levels generally will exceed 1000 units per liter. Empyema is when fluid fills your lungs, leading to an infection.(f) viral meningitis (easily spreads through crowded population, such as college campuses and large urban areas)(g) encephalitis (caused by moquitoes that carry the disease)Source(wikipedia)
LDH enzyme (subtype 4H) is very abundant in red blood cells and heart muscle. In vit B12 deficiency there is high destruction of red cells in the bone marrow and in the blood vessels. As RBCs ruptures they release their inner content into the blood stream. So that's how LDH goes up in the blood.
In my case, I was told "non-alcoholic fatty liver." High blood cholesterol may cause high SGOT/AST and a specific LDH "type" (they can tell from whence the LDH originates) may be elevated. If they said liver, then fatty liver is usually the culprit. Habitual alcohol or certain medication use may cause fatty liver as well. Losing weight is said to help lower those two. Lowering blood cholesterol is important to help the "fatty liver" lessen it's load. In my case, years pass and more bloodwork reveals the same, plus leukemia and lymphoma. I am in poor general health, so I think the high AST & LDH are from the fatty liver and not the cancers. A CBC will inform your doctor if there are abnormalities that would point him/her away from fatty liver.
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Lactate Dehydrogenase
serum enzyme tests
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A LDH test is short for a test for Lactic Dehydrogenase test which is used by doctors to measure the amount and severity of tissue damage in an individual.
There are several enzyme levels in the body that are only indicative of illnesses when taken in context with other abnormal labs. Examples of these would be LDH, CRP and alkaline phosphatase. These tests are more useful in confirming the diagnosis determined from more specific tests as no abnormalities in liver, heart or muscles. We would need to look at the full panel of lab tests to determine if an elevated LDH level was significant.
ldh