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An abnormally thin dendritic spine can yield poor neural impulse conduction; and drugs like LSD which mimic neurotransmitters may "clog" receptors & cause continued activation, I think. I suspect there could also be problems with the PRODUCTION of neurotransmitters or with the conveyance of vesicles containing NT to the synapse.

Synapses are spaces or junctions between two neurons. The principle of synapse works on mechanism of neuro-transmitters and neuro-inhibitors.

When a nerve impulse reaches the end of one neuron to travel to the next one, at that moment acetylcholine is produced in the synapse. Acetyl choline being a neurotransmitter helps to transmit the nerve impulse.

Right after the nerve impulse has passed through the synapse, a neuroinhibitor such as cholinesterase si produced to stop the action of acetylcholine.

At a particular synapse, these two chemicals are produced at a very high rate. This is how a nerve impulse works. But suppose if the production of these two chemicals is affected, the synapse will not function properly.

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Q: What can cause synapse to not function correctly?
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