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Every few series or so, the Doctor regenerates. When he is in critical condition, he becomes a different person (only visually, his personality doesn't change all that much) and thus a new actor is shown. (e.g. Christopher Eccleston "regenerates" into David Tennant.)

The real reason behind this is because the actor's contract with the show ended, whether by choice or by force.

At the end of the Fifth Doctor story "The Caves of Androzani", The Doctor and his companion Peri are exposed to a lethal dose of toxic 'Spectrox'. With only one dose of antidote, the Doctor saved Peri, and then regenerated into the Sixth Doctor, played by Tom Baker.

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