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Type I Osteogenesis Imperfecta is the most common and mildest type of this disease. In this type the Scleras (whites of the eyes) usually have a blue, purple, or gray tint.

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Q: What causes blue sclerae in osteogenesis imperfecta?
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What causes blue sclera in osteogenesisis imperfecta?

The underlying deficiency in OI is a defective Type I Collagen. Because this doesn't form correctly the sclera ends up being thinner than normal. This makes it easier to see the underlying choroidal veins which give them a blue-gray coloration.


What causes blue scleral?

It is caused by a thin sclera and quite frequently seen in new born babies. It should disappear in 3 -6 months time. Rarely it can be due to a congenital disease called brittle bone disease - Ostetoegenesis imperfecta.


Can you list the congenital abnormalities in skeletal system among children?

Transitional vertebra - A vertebra that takes on the characteristic of the vertebra on either side of it. · Example a cervical vertebra with a rib attached Spina Bifida -A posterior defect of the spinal canal resulting from failure of the posterior elements to fuse properly Osteopetrosis "Marble Bone"- There in an increase in bone resorption Osteogenesis imperfecta - "Brittle Bone Disease" · The skeleton does not ossify properly. · Often characterized by a blue coloration of the white sclera of the eye Acondroplasia - Failure of cartilage that becomes bone to form properly. Causes dwarfism


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What cause the sclera turn brown?

There are 3 main colours that your sclera can go- red/blue/yellow. A blue sclera is usually due to a condition known as osteogenesis imperfecta. This is a genetic bone disorder which results in a deficiency in the connective tissue throughout the body. The sclera contains connective tissue. The reason that the sclera appears blue is that the sclera is very thin in this condition so you can see the underlying choroid. A yellow sclera occurs with age. This is basically due to fatty deposits in the sclera causing a yellow appearance. Red sclera means blood. This can be a result of either episcleritis or scleritis. Episcleritis is a sudden, painless redness of the eye and is easily treated. Scleritis is a gradual onset of a painful, red eye and it is considered to be of medical urgency as if left untreated, it can lead to blindness.


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