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Given thatI am unclear as to the exact isotopes of Oxygen, I would assume that the only difference between them are the change is mass number. i.e there may be (one [1]) less or (one [1]) more neutron(s) in the nucleus of the oxygen atoms. This is the easiest explanation for what an isotope of any element is. Mass spectrometry is used to determine the exact mass number of each element, given that (to my knowledge), all elements have isotopes. For this reason, elements tend to have fractions of grams. For example, the exact mass number / relative molecular mass (RMM)/ Relative Atomic Mass (RAM) / Relative Formula Mass (RFM) (usually considered the same/closely related), for Oxygen is 15.9994g, usually taken at 16, is determined by the abundance of each isotope. Hint: the final mass number of element is nearest the most abundant isotope.

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Q: What chemical differences do you expect between the three isotopic forms of oxygen?
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