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prostate cancer. usually as a rule if pain is waking you from sleep with no exceptional cause it is known as a "red-flag" in healthcare

also if you commonly have sweats during sleep and this pain linked it is fairly likely to be a space occupying lesion - tumor.

unless he hasn't defecated in a while..

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Q: What could be the cause of a man waking up from a sound sleep getting out of bed to use the bath room and out of no where be overwhelmed with extreme pain in the rectum?
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