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What do chief cells secrets?

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Anonymous

12y ago
Updated: 12/4/2022

Chief cells secret pepsinogen and gastric lipase. Pepsin, the activated form of pepsinogen, can break down proteins into peptides and gastric lipase can break down trigylcerides into fatty acids and monoglycerides.

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What is the difference between parietal cells and chief cells?

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Parietal cells are found in gastric mucosa and secretes hydrochloric acid in stomach. They are also known as Chief cells or oxyntic cells.?

Parietal cells (or oxyntic cells) are epithelium cells found in the gastric mucosa, they secrete hydrochloric acid (HCl) and intrinsic factor (which is required for vitamin B12 absorption). Chief cells are not the same as parietal cells. Chief cells secrete pepsinogen and rennin.


How are chief cells activated?

Gastric chief cells (as opposed to the chief cells present in the parathyroid gland) are the zymogen cells in the stomach that release pepsinogen (a precursor (zymogen) of pepsin). Without stimulation chief cells normally secrete pepsinogen at about 20% of the maximum ability. ACh (released by nerves) is the most important pathway for gastric chief cell activation. ACh also stimulates parietal cells, which secrete HCl (stomach acid). The fall in pH causes a reflex which further stimulates chief cells. Alternatively, acid in the duodenum (the first portion of the small intestine), stimulates release of secretin from S cells of the small and large intestine. Secretin also activates gastric chief cells.