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How are chief cells activated?

Updated: 11/2/2022
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11y ago

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Gastric chief cells (as opposed to the chief cells present in the parathyroid gland) are the zymogen cells in the stomach that release pepsinogen (a precursor (zymogen) of pepsin). Without stimulation chief cells normally secrete pepsinogen at about 20% of the maximum ability.

ACh (released by nerves) is the most important pathway for gastric chief cell activation.

ACh also stimulates parietal cells, which secrete HCl (stomach acid). The fall in pH causes a reflex which further stimulates chief cells.

Alternatively, acid in the duodenum (the first portion of the small intestine), stimulates release of secretin from S cells of the small and large intestine. Secretin also activates gastric chief cells.

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Q: How are chief cells activated?
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Related questions

What do chief cells do?

Chief cells secret pepsinogen and gastric lipase. Pepsin, the activated form of pepsinogen, can break down proteins into peptides and gastric lipase can break down trigylcerides into fatty acids and monoglycerides.


What do chief cells in the stomach secret?

The chief cells secret pepsinogen and gastric lipase. The activated form of pepsinogen (i.e. pepsin) can break down proteins into peptides. As for the lipase, it can split trigylcerides into fatty acids and monoglycerides.


What do chief cells secrets?

Chief cells secret pepsinogen and gastric lipase. Pepsin, the activated form of pepsinogen, can break down proteins into peptides and gastric lipase can break down trigylcerides into fatty acids and monoglycerides.


What cells produce pepsinogen and hcl?

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