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Show them what the Church teaches on in vitro fertilization (CCC 2376-2377)*, then tell them that they can be forgiven of their sin through Baptism (if they aren't Baptized) (CCC 1263), or if they are already Baptized, through Confession. Although, I assume they don't meet the three requirements for Mortal Sin (Full knowledge, full consent, grave matter**), so they wouldn't necessarily need to go to Confession, although it would probably be good for their souls if they did (assuming they aren't Baptized).

*(CCC #) is Catechism of the Catholic Church with cited paragraph number.

**YES! This sin IS grave matter!

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Q: What do you tell someone who has had in vitro insemination and wants to become Catholic?
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