Deletions and duplications of single-base pairs typically arise during homologous recombination and cause diseases. But what happens when a mutation occurs over multiple genes?
Rearrangements of chromosomes include deletions of DNA sequences and duplications of segments, both of which can encompass thousands to hundreds of thousands of bases. Why do these large rearrangements occur? For one, certain structural features of the genome, also referred to as genome architecture, can render various regions fragile and thus prone to events such as chromosome breakage, which often result in translocations, deletions, and duplications. Often, these alterations happen due to errors during cell division when chromosomes align (Figure 1). Homologous recombination between areas of concentrated repeated sequences frequently creates deletions and duplications. Because they commonly involve more than one gene, the disorders caused by these large deletion and duplication mutations are often severe.
Duplication mutations occur when a DNA sequence is duplicated or replicated resulting in multiple copies in the region.
a mutation
Inversion and duplication!
mutation
true
Mutation can create new alleles, therfore can change allele frequencies in a population.
The mutation in which a segment of a chromosome is repeated is known as duplication.
a mutation
Inversion and duplication!
mutation
true
Mutation can create new alleles, therfore can change allele frequencies in a population.
Deletion, insertion, inversion, translocation, and duplication [for the ppl. Who dnt kno!!]
ture
Deletion, duplication, inversion, translocation.
Insertion, Deletion and Frameshift mutation. These are the 3 basic types of mutation, however, there are other types of mutations: substitution, translocation, duplication, inversion, transversion and transition.
They include: trans-location, deletion, duplication and inversion. A chromosome mutation is an unpredictable change that occurs in a chromosome.
gene duplication (might give advantages)