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Almost none. The black plague may have taken out half of Europe's population in the late 1300's. Believed to have been spread by fleas and rats by modern scholars, but no attempt was even made to isolate or study the source, spread or treatment of the pandemic at the time.

The plague may have re-emerged every generation until the 1700's.

Modern medicine was more affected by wars and battlefields than medieval diseases.

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Q: What effect did the Black Plague have on medicine in Western Europe?
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