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It is said that the cimetidine will potentiate the oxycontin. It is supposed to prolong the effectiveness of the drug.

The Tagamet HB (Cimetidine) is a broad CYP450 inhibitor. This basically means it 'clogs' the enzymes that metabolize opiates\opioids and clear 'em out of the body. Tagamet HB tablets are 200mg each, so the recommended 600mg is 3 tabs. They're OTC, and you can get a box of 50 generic 200mg cimetidine tabs at CVS for like $5.49. There are several posts on the web about this. Hope this helps!!

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Q: What effect does cimetidine have with oxycodone or xanax?
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