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Phase I: Lipophilic drugs need to become more polar so that they can be excreted in urine. New polar functional groups hence need to be unmasked for added to them. This can happen via oxidation, reduction, or hydrolysis.

Phase II: The original drug or drug metabolites gets conjugated to acetate, sulfate, glutathione, or glucuronic acid. They can hence be excreted even more quickly due to their increased polarity.

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