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What happens in the bone marrow of people with aplastic anemia?
GaleEncyofMedicine
The basic structure of the marrow becomes abnormal, and those cells responsible for generating blood cells (hematopoietic cells) are greatly decreased in number or absent.
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∙ 13y ago
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Can anemia lower your ability to fight off infections?
Anemia affects red blood cells usually, and doesn't always lower the immune system response but aplastic anemia (a.k.a bone marrow failure) causes the body to produce less red blood cells, WHITE blood cells, and platelets. Therefore, I believe, anemia can lower your ability to fight off infections (if the amount of white blood cell production is lowered). the above answer is true but people with sickle-cell anemia have a greater resistance to malaria. Also aplastic anemia patients have just as much troube as fighting a VIRUS as any other person.
How does mia hamm do now to make a living?
The Mia Hamm Foundation was created after he brother Garret died in 1997 from Aplastic Anemia. The foundation is used to raise money for people who need bone marrow transplants and also to raise bone marrow awareness.
Who benefits from the bone marrow transplants?
People who are sufferers of diseases pertaining to their blood. For instance bone marrow transplants are given to patients suffering from Leukemia and Sickle Cell Anemia
Idiopathic aplastic anemia?
DefinitionIdiopathic aplastic anemia is a condition in which the bone marrow fails to properly make blood cells. Bone marrow is the soft, fatty tissue in the center of bones.See also:AnemiaSecondary (acquired) aplastic anemiaAlternative NamesAnemia - idiopathic aplasticCauses, incidence, and risk factorsAplastic anemia results from injury to the blood stem cells, immature cells in the bone marrow that give rise to all of other blood cells types. The injury causes a decrease in the number of every type of blood cell in the body -- red cells, white cells, and platelets. Low numbers of red cells, white cells, and platelets is a condition called pancytopenia.Idiopathic means the cause is unknown. However, idiopathic aplastic anemia is thought to occur when the body reacts against its own cells. This is called an autoimmune disorder.The disease may be acute or chronic, and may get worse over time. There are no known risk factors.Aplastic anemia may also be caused by certain medical conditions (such as pregnancy or lupus) or exposure to some toxins or drugs (including chemotherapy). See: Secondary (acquired) aplastic anemiaIn some cases, aplastic anemia is associated with another blood disorder called paroxysmal nocturnal hemoglobinuria (PNH).SymptomsSymptoms are the result of bone marrow failure and the loss of blood cell production.Low red cell count (anemia) leads:FatiguePallor(paleness)Rapid heart rateShortness of breath with exerciseWeaknessLow white cell count (leukopenia) causes an increased risk of infection.Low platelet count (thrombocytopenia) results in bleeding, especially of the mucous membranes and skin. Symptoms include:Bleeding gumsEasy bruisingFrequent or severe infectionsNose bleedsSigns and testsLow red blood cell count (anemia)Low white blood cell countLow reticulocyte count (reticulocytes are immature red blood cell)Low platelet countBone marrow biopsy shows an overall decrease in the number of blood cellsTreatmentMild cases of aplastic anemia may be treated with supportive care or may require no treatment.In moderate cases, blood transfusions and platelet transfusions will help correct the anemia and the risk of bleeding. However, over time, blood transfusions may stop working.Too much iron may build-up in the body tissues may occur because of the many transfusions. See HemochromatosisSevere aplastic anemia occurs when blood-cell counts are very low, and is a life-threatening condition. Bone marrow transplant or stem cell transplant is recommended for severe disease in younger patients. However, they must have a donor who is a sibling (brother or sister) and a good match. This is called a matched sibling donor.For older patients, or for those who do not have a matched, related bone marrow donor, anti-thymocyte globulin or other drugs that suppress the immune system may allow the bone marrow to once again make blood cells. A bone marrow transplant with an unrelated donor may be tried if these medications do not help, or if the disease comes back after getting better.Expectations (prognosis)Untreated aplastic anemia leads to rapid death. Bone marrow transplant has been successful in young people, with long term survival rates of about 80%. Older people have a survival rate of 40 - 70%.ComplicationsSevere infections or bleedingComplications of bone marrow transplant (graft failure or graft-versus-host disease)Reactions to medications (patients can have reactions to anti-thymocyte globulin)Calling your health care providerCall your health care provider or go to the emergency room if bleeding occurs for no reason, or if bleeding is difficult to stop. Call if you notice frequent infections or unusual fatigue.PreventionThere is no known prevention for idiopathic aplastic anemia.ReferencesCastro-Malaspina H, O'Reilly R. Aplastic anemia and related disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 171.
What happens in Sideroblastic Anemia?
Abnormal, iron-saturated red cells are present in the blood of people who have this disease. Although the iron circulates normally from the plasma to the bone marrow, where new red blood cells are created, it is not properly incorporated
Who benefits from bone marrow transplant?
People with different types of cancers or diseases from Leukemia to Sickle Cell Anemia can benefit from a Bone Marrow Transplant. Basically when someones blood or immune system is not working and needs replaced
What is the differanse in cancer and leukemia?
Leukemia and blood cancer are terms that are sometimes used interchangeably, but they have specific meanings within the context of medical terminology: Leukemia: Leukemia is a type of cancer that starts in the bone marrow, where blood cells are produced. It specifically affects the white blood cells, which play a crucial role in the body's immune system. In leukemia, the bone marrow produces abnormal white blood cells that do not function properly and may crowd out healthy blood cells. Leukemia can be categorized into different types based on the speed of cell growth and the type of white blood cells affected. The main types include acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML). Symptoms of leukemia may include fatigue, frequent infections, bruising, bleeding, pale skin, and swollen lymph nodes. Blood Cancer: Blood cancer is a broader term that encompasses various types of cancers that affect the blood, bone marrow, and lymphatic system. Blood cancer includes not only leukemia but also other types of cancers that involve abnormal cell growth within the blood and bone marrow. These may include lymphomas and myelomas. Lymphomas are cancers that start in the lymphatic system, which is part of the immune system. They can be categorized as Hodgkin lymphoma or non-Hodgkin lymphoma. Myelomas are cancers that start in plasma cells, which are a type of white blood cell that produces antibodies to help fight infections.
What is the difference between anemia and hemophilia?
Anemia is a generic term referring to "inadequate oxygen capacity in the blood"; anemia can be caused by anything from excessive blood loss to parasites on the red blood cells to inadequate red blood cell formation in the bone marrow. Hemophilia is a more specific term referring to "inadequate blood clotting capacity"; there are multiple types of hemophilia but they are all bleeding disorders. It is very common for people with hemophilia to develop anemia. However, very few people who have anemia also have hemophilia.
Some Facts About Bone Marrow Transplant?
A bone marrow transplant is the transplant of marrow cells and blood from a healthy person to a person who is in need of marrow and blood cells. The healthy blood and marrow replace the diseased cells of the sick person. The marrow cells are stem cells, which means they can develop into red blood cells, white blood cells and platelets.Who Needs a Bone Marrow Transplant?People who have blood cancers like leukemia may need bone marrow transplants. Leukemia is a malignant overgrowth of white blood cells in the bone marrow, the lymph glands, the spleen, the liver or other organs that are part of the lymphatic system. Other candidates for the transplant are:People whose suffer from thalassemias, where the red blood cells contain less hemoglobin than normal.People who suffer from aplastic anemia, where the bone marrow doesn't produce enough blood cells.People who suffer from sickle cell anemia, where the red blood cells are deformed and can't carry hemoglobin properly. Sickle cell anemia causes episodes of extreme pain and chronic poor health and can be life threatening.Sometimes radiation and chemotherapy can damage bone marrow to the point where it can't produce blood cells, so a bone marrow transplant is needed.Who Gives a Bone Marrow Transplant?The patient can give a bone marrow transplant to themselves. If the patient was healthy and had to have treatment where the destruction of their bone marrow was a possibility, they can have their bone marrow stem cells stored.Other bone marrow transplants come from a donor. The problem here is that the donor's stem cells have to match the patient's very closely. Sometimes, even a brother, sister or parent isn't a match for the patient and there might be a wait till a donor is found.Sometimes the donor cells come from umbilical cord blood.How Is Bone Marrow Collected?Nowadays, doctors rarely perform the painful procedure where marrow is taken out of the donor's hip, but in most cases a needle withdraws blood from the donor's arm. The stem cells are removed from the blood and what's left of the donor's blood is returned to them.
Did Marie Curie die from cancer?
Madame Curie made two trips to America to receive a gram of radium each time, first from President Warren Harding and eight years later from President Herbert Hoover. In 1923 the French government gave her a pension of 40,000 francs a year in recognition of her lifetime of work in France. She became ill and died from all her years of exposure to radium. Today doctors identify the disease as leukemia. After Marie's death her daughter Irene and her husband Frederic Joliot received the Nobel prize for their work in atomic research. She followed in her mother's footsteps to also become a great scientist. Many people have benefited from the discoveries made by Pierre and Marie Curie. The radiation which burned their skin as they worked with it, eventually came to be used to kill cancer cells in patients suffering from the disease.
When are red blood cells used in a blood transfusion?
They are given to people who have anemia (including thalassemia ), whose bone marrow does not make enough RBCs, or who have other conditions that decrease the number of RBCs in the blood.
How many people have anemia?
I think that about 1 billion people in the U.S have anemia
