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Certain functional groups on the chemical structure of drugs are capable of being protonated/ deprotonated based on the pH of the solution (amine groups as well as carboxylate groups are capable of this). Changing the pH of the solution can change the physical chemistry of a drug by adding or removing protons at certain sites of the molecule. Depending on the molecule, this will either increase or decrease the solubility of the drug.

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Q: What is Effect of pH in the solubility of weak acidic drugs?
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