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What is Flecainide?

Updated: 12/14/2022
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11y ago

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Flecainide acetate

is a class Ic

antiarrhythmic agentused to prevent and treat

tachyarrhythmias(abnormal fast rhythms of the

heart). It is used to treat a variety of cardiac arrhythmias including paroxysmal

atrial fibrillation(episodic irregular heartbeat originating in the upper chamber of the

heart), paroxysmal

supraventricular tachycardia(episodic rapid but regular heartbeat originating in the atrium), and

ventricular tachycardia(rapid rhythms of the lower chambers of the heart). Flecainide works by regulating the flow of

sodiumin the heart, causing prolongation of the

cardiac action potential.

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Q: What is Flecainide?
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What are some antiarrhythmics?

sotalol, flecainide, propafenone, digoxin, verapamil, ibutilide, quinidine, amiodarone just to name a few


Can flecainide cause high blood pressure?

I hope to have a proper answer to this question soon. I was prescribed 100mg flecainide twice a day, everything seemed to be fine. After a month I noticed that I had gone into atrial fibrillation and since I knew the onset was very recent I took three 100mg flecainide as advised by my doctor. I went back to sleep and when I woke up my arrhythmia was gone but I felt a little unwell. I checked my BP and is was 190/105 which I found almost unbelievable and quite frightening. I did my best to stay calm and have a stress free day and it slowly fell but I noticed that my usual systolic pressure was a lot higher than usual 140 - 150 / 75 instead of my usual average of 125/75. I have temporarily stopped taking the flecainide and my systolic BP has fallen by 10 - 15 in the last two days. I will be seeing my doctor soon and find out if there is anything different that needs to be done to avoid arrhythmia and high BP. Male, 46, lone paroxysmal AF (four times in five years), BP usually 125/75, resting pulse 55.


Can flecainide get you high?

NO! It is an anti-arrhythmic, which slows down your heart, but usually is only used in serious heart conditions. It's effect is directly on your heart, not on your central nervous system so it doesn't work to get you "high".


Can you exercise taking flecainide?

Firstly it will depend on why you are taking flecainide. If the reason or another condition precludes exercise the answer is clearly NO.However if you are taking flecainide for a reason which does not preclude exercise then the answer is YES. Of course almost all heart conditions will benefit from appropriate exercise.Using myself as an example - and there are others. I have atrial fibrillation and take flecainide 150mg as a "pill in pocket" (ie when I have episodes). My episodes generally last 4 to 20 hours, sometimes much longer. I have them 25% to 50% of the time and they started about 10 or so years ago.I exercise fairly vigorously most days of the week but now limit the time to 25 to 45 minutes per session. I go kayaking for longer but this is much less intense. I jog, cycle do some weights and kayak. I generally feel much better for exercising.I therefore take flec most days. I was on regime of taking 150mg flec morning and evening - to give a steady dose. I continued to exercise. I have found that for me taking flec as a "pill on pocket" works much better and I take less.I will exercise when in AF. I take the flecainide shortly after a bout of AF starts. However I do not take when exercising, I wait till I have finished. Two reasons for this. Firstly most recommendation suggests rest after taking so the chance is it will not be as effective if taken when exercising, despite the idea that taking it as soon as possible is better. Secondly exercise can cause my pulse to revert to NSR though this is rare now that my exercise periods are shorter.See my blog at http://arrhythmiarules.blogspot.com/Endurance exercise is generally shown to be not helpful for AF.


Could you die from accidental overdose of flecainide?

I don't know but I sure hope not because the druggist has been giving me the wrong strength for over a month.I was taking double the dosage that was prescribed by my Dr.The druggist didn't have the 50 mg. so he gave me 100 mg.& FORGOT to tell me to cut them in half.And when my Dr. upped my script to 150 mg.I was taking 300 mg. I have to go for a cardiogram today. Sharon


Arrhythmia Treatment?

Doctors may prescribe various treatments for arrhythmia problems, medications, catheter ablation or even surgery. Common medications include the beta blockers metoprolol (brand names Toprol XL, Lopressor), atenolol (Tenormin), carvedilol (Coreg), etc. Others include digoxin, diltiazem (Cardizem, Cartia), which just like the beta blockers are primarily used to slow rapid heart rates. Antiarrhythmic medications designed to prevent the onset of a rapid rhythm include flecainide (Tambocor), amiodarone (Cordarone, Pacerone), dronederone (Multaq), sotalol (Betapace) and propafenone (Rhythmol). Catheter ablation is a heart procedure where long wires or catheters are inserted from a groin vein into the heart where heat energy is applied in an attempt to permanently cure a rapid arrhythmia. Rarely, open heart surgery similar to coronary bypass surgery is needed to allow for treatment of challenging arrhythmias such as refractory atrial fibrillation. Cardiac implanted electrical devices (CIEDs) include permanent pacemakers used to treat slow heart rhythms, implantable cardioverter defibrillators (ICDs) to treat life-threatening ventricular tachycardia (VT) and biventricular or cardiac resynchronization devices to treat both VT and heart failure.


How can sodium channel blockers terminate re-entry in cardiac arrhythmia?

Cardiac arrhythmia is cause by the presence of an ectopic focus or a re-entry mechanism where an action potential is delayed for some reason and enters nearby muscle fibres that are no longer refractory causing depolarisation and establishing a circuit movement. There are three classes of anti-arrhythmic drugs which block sodium channels: Class IA drugs block open Na+ sodium and can increase the effective refractory period. They produce a frequency-dependent block As they dissociate slowly away from these Na+ channels, they can prevent the Na+ channel from contributing towards an action potential if the frequency is high. Disopyramide one such example. It is used to treat ventricular arrhythmia by resulting in a negative inotropic effect. Class IB drugs block closed Na+ sodium. It is often used to treat ventricular arrhythmia after an acute myocardial infraction. Lidocaine is one such example. It has little effect on normal cardiac tissues as it dissociates quickly from the Na+ channels. However, many Na+ channels are closed in ischemic cases due to anoxia. Lidocaine can hence act on these closed Na+ channels. Class IC drugs are the most potent when it comes to blocking Na+ channels. They slowly dissociate from the Na+ channels and it leads to depressed conduction in the myocardium. These agents can prolong the RP and QRS intervals. Flecainide is one such example and it is used the treat atrial fibrillation.


What meds can you take and not take while on methadone?

Talk to your doctor. Talk to you pharmacist. Also see the related link below. Do not take this medicine with any of the following medications: •antibiotics like chloroquine, clarithromycin, erythromycin, grepafloxacin, pentamidine, sparfloxacin, troleandomycin •arsenic trioxide •cisapride •droperidol •halofantrine •haloperidol •medicines for irregular heart beat like amiodarone, bretylium, disopyramide, dofetilide, procainamide, quinidine, sotalol •pimozide •ranolazine •rasagiline •selegiline •sertindole •ziprasidone This medicine may also interact with the following medications: •alcohol •alfuzosin •antibiotics like gatifloxacin, gemifloxacin, levofloxacin, mefloquine, moxifloxacin, ofloxacin, telithromycin •antihistamines for allergy, cough and cold •desipramine •MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate •medicines for blood pressure •medicines for depression, anxiety, or psychotic disturbances •medicines for irregular heart beat like flecainide, propafenone •medicines for nausea or vomiting like dolasetron, ondansetron, palonosetron •medicines for seizures like carbamazepine, phenobarbital, phenytoin •medicines for sleep •medicines for sleep during surgery •medicines to numb the skin •muscle relaxers •narcotic medicines for pain •octreotide •peginterferon Alfa-2b •phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine •rifampin, rifapentine •some medcines for cancer like dasatinib, lapatinib, sunitinib •some medicines for HIV like delavirdine, didanosine, efavirenz, nevirapine •St. John's wort •tacrolimus •tramadol •vardenafil •vorinostat This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


Paroxysmal supraventricular tachycardia (PSVT)?

DefinitionParoxysmal supraventricular tachycardia (PSVT) is an occasional rapid heart rate. "Paroxysmal" means from time to time.Alternative NamesPSVT; Supraventricular tachycardiaCauses, incidence, and risk factorsNormally, the chambers of the heart (atria and ventricles) contract in a coordinated manner. The contractions are caused by an electrical signal that begins in an area of the heart called the sinoatrial node (also called the sinus node or SA node). The signal moves through the upper heart chambers (the atria) and tells the atria to contract.PSVT starts with events taking place above the lower heart chambers (ventricles). PSVT can be initiated in the SA node, in the upper heart chambers (atria), in the atrial conduction pathways, or other areas.PSVT can occur with digitalis toxicity and conditions such as Wolff-Parkinson-White syndrome.The condition occurs most often in young people and infants.The following increase your risk for PSVT:Alcohol useCaffeineuseIllicit drug useSmokingSymptomsAnxietyChest tightnessPalpitations (a sensation of feeling the heart beat)Rapid pulseShortness of breathAdditional symptoms that may be associated with this condition:DizzinessFaintingNote: Symptoms may start and stop suddenly, and can last for a few minutes or several hours. A PSVT lasting more than half of the day is considered an incessant PSVT.Signs and testsA physical examination during a PSVT episode will show a rapid heart rate.The heart ratemay be 150 to 250 beats per minute (bpm). In children, the heart rate tends to be very high. There may be signs of poor blood circulation such as lightheadedness. Between episodes of PSVT, the heart rate is normal (60 to 100 bpm).An ECG during symptoms shows PSVT. An electrophysiology study(EPS) is often necessary for an accurate diagnosis and to recommend the best treatment.Because of the sporadic nature of the PSVT, its diagnosis may require 24-hour Holter monitoring. For longer recording periods, a "loop recorder" (with computer memory) is used.TreatmentIf you do not have symptoms, PSVT may not require treatment.If symptoms occur or if you have another heart disorder, treatment may be necessary.If you have an episode of PSVT, a technique called the Valsalva maneuver can be used to interrupt the fast heartbeat. Hold your breath and strain, as if you were trying to have a bowel movement, or cough while sitting with your upper body bent forward.Splashing ice water on the face has been reported by some people as helpful.Emergency treatment of PSVT may include:Electrical cardioversion, the use of electric shock to restore a rapid heartbeat back to normal.Medicines through a vein, including adenosine and verapamil. Other medications may be used, such as procainamide, beta-blockers, and propafenone.Long-term treatment of PSVT may include:Daily medications such as propafenone, flecainide, moricizine, sotalol, and amiodarone.Pacemakers to override the fast heartbeat; very occasionally used in children with PSVT who have not responded to any other treatment.Radiofrequency catheter ablation; currently the treatment of choice for most PSVTs.Surgery to change the pathways in the heart that send electrical signals; this may be recommended in some cases for people who need other heart surgery.Expectations (prognosis)PSVT is generally not life threatening, unless other heart disorders are present.ComplicationsThe main complication is an increased risk of heart failure.Calling your health care providerCall your health care provider if:You often have a sensation of excessive palpitations and symptoms do not end on their own in a few minutesYou have a history of PSVT and an episode does not go away with Valsalva maneuver, or if other symptoms go along with the rapid heart rateSymptoms return frequentlyNew symptoms developPreventionAvoid smoking, caffeine, alcohol, and illicit drugs. Medications used to treat the disorder may be given as a preventive (prophylactic) treatment in people at a high risk or who have had previous episodes of PSVT.ReferencesOlgin JE, Zipes DP. Specific arrhythmias: diagnosis and treatment. In: Libby P, Bonow RO, Mann DL, Zipes DP, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. St. Louis, Mo: WB Saunders; 2007:chap 35.


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