Phenylpropanolamine.
clement
deputy
humanhey
Rameshwaram
Here's an example of a five letter word which reads the same when the first and last letters are dropped: gnome and nom (as in 'nom de plume')
empty
empty
The word is "sun." In this riddle, "the first of the first" refers to the first letter of the word "sun," which is "s." The second and third letters are "u" and "n," which represent "nothing." Lastly, "the first of last" refers to the first letter of the word "last," which is "l."
Car, the, wow, His, Her, Him, She. Any three letter word
asuras
Tragic
HEART The first four letters 'hear' refer to the function of the middle three letters, 'ear.' The last three letters 'art' is stuff that you do.