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Pressure is a statistical mechanic variable, representing the force exerted on a unit surface by a body that is composed by a huge number of particles, sufficiently great to apply statistical methods to average the fluctuating force exerted in time due to the interaction of individual particles with the surface.

A molecule is not composed by a sufficient number of particle generally, and, more important, the chemical bonds composing it gives to the molecule an ordered structure, so that pressure cannot be rigorously defined talking about molecules.

In some application, when dealing with solutions of very big molecules, like proteins or polymers chains, the interaction of these big molecules with the solvent, for example water, is modelled as the interaction of a body constituted by several rigid sphere bonded together (the molecule) with a continuous background medium (the solvent). This approximation, that is called implicit solvent approximation, is allowed by the fact that the solvent molecules are much smaller than the solute molecules. In this context it is possible to say that the solvent exert a pressure on the molecule surface, that naturally depends on many parameters like temperature, density of the solution, and so on, besides the nature of solvent and solute.

This is however a simpling model, that is used only because frequently a fully molecular model, where both solvent and solute are represented as molecules populations, is too hard to be solved.

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Q: What is a high-pressure area of tightly-packed molecules?
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