There are two:
slavery
Political issues are divided between two major parties.
The issue of predestination was the major issue especially between calvinists and Lutherans.
Republican
The expansion of slavery into the territory west of Missouri
what to do about Russian control of the pacific coast
The major issue in the era of the democrats between 1800-1860 was slavery and high tariffs.
The tariff of abominations, also known as the Tariff of 1828, became a major campaign issue in the 1828 presidential election. It was a contentious issue that led to significant division between different regions and political parties, particularly between the North and South. The outrage caused by the tariff helped Andrew Jackson secure his victory in the election.
The major issue between southern and northern states was the problem of slavery. The North had abolished it and the South wanted to keep it.
Kashmir is the basic issue between the two countries. Because of this issue both countries have fought many wars.
Cheap production of goods
d