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A negative mutation is one which is harmful to the organism. The result of a negative mutation is a non-sense protein. Examples of negative mutations include:

  • a frame shift mutation - codons are read wrong
  • an insertion mutation - insertion of a sequence of extra nucleotides
  • a deletion mutation - deletion of a chain of nucleotides
  • a non-sense mutation - results in the creation of a non-sense protein
  • a transition mutation - exchange of purines to pyrimidines thus changing the nucleotide sequence and resulting in a mutation.
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15y ago
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16y ago

Mutation resulting in a gene product that can interfere with the function of the normal gene product in heterozygotes.

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14y ago

A negative mutation is when a gene mutation happens and something bad happens. You get a disease or something like that. A disease like Down's Syndrome.

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Q: What is dominant negative mutation?
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What is an example of a lethal dominant mutation?

the example of lethal dominant mutation is huntington's disease.


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What is the difference between genetic a disorder and a genetic mutation?

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