What is x linked inheritance diseases?

Answer 1

X-linked genes are found on the sex X chromosome. X-linked genes just like autosomal genes have both dominant and recessive types. Recessive X-linked disorders are rarely seen in females and usually only affect males. This is because males inherit their X chromosome and all X-linked genes will be inherited from the maternal side. Fathers only pass on their Y chromosome to their sons, so no X-linked traits will be inherited from father to son. Females express X-linked disorders when they are homozygous for the disorder and become carriers when they are heterozygous. An infamous recessive X-linked disorder is Hemophilia A. Hemophilia is a disorder where blood does not clot properly due to a shortage of clotting factor VIII. This disorder gained recognition as it traveled through royal families, notably the descendent's of Britain's Queen Victoria. X-linked dominant inheritance will show the same phenotype as a heterozygote and homozygote. Just like X-linked inheritance, there will be a lack of male-to-male inheritance, which makes it distinguishable from autosomal traits. One example of a X-linked trait is Coffin-Lowry syndrome, which is caused by a mutation in ribosomal protein gene. This mutation results in skeletal, craniofacial abnormalities, mental retardation, and short stature. X chromosomes in females undergo a process known as X inactivation. X inactivation is when one of the two X chromosomes in females is almost completely inactivated. It is important that this process occurs otherwise a woman would produce twice the amount of normal X chromosome proteins. The mechanism for X inactivation will occur during the embryonic stage. For people with disorders like trisomy X, where the genotype has three X chromosomes, X-inactivation will inactivate all X chromosomes until there is only one X chromosome active. X inactivation is not only limited to females, males with Klinefelter syndrome, who have an extra X chromosome, will also undergo X inactivation to have only one completely active X chromosome.

Answer 2

An X-linked disorder is a disease that mostly men carry. Males only have one X-chromosone so if they get a disease-creating gene on the X-chromosome males don't have a backup to fight off the disease so there will carry an X-linked disease. Women have two X-chromosone's so are less likely to get it since they have a backup.

Answer 3

Huntington's is a progressive neurologic disease that is X-linked. Also, male pattern baldness is X-linked.

Answer 4

X-linked recessive disorder identifies location of the gene causing the disorder as being located on the X chromosome.