Fare is misshapen with his back
The root word of misshapen is "shape."
Misshapen pupils can be caused by several things such as iridocyclitis or iritis. The medical term for misshapen pupils is synechia.
The nose of the statue was misshapen because of heavy rain
The lady was very misshapen ,because she wasn't eating write.
The misshapen hot air balloon drifted slowly toward the line of trees.
happen, basin, raisin, etc...
Knotty and twisted.
Missense mutation
Misshapen, monstrous
The adjective is spelled gnarled (twisted, misshapen).
They are not biological and don't "replicate" in a biological sense. They are misshapen proteins and they cause other proteins to also become misshapen, and thus cells just come apart or die.