an excess of a product of one reaction causes the enzyme of another reaction to stop working.
Feedback inhibition works when the product of the process is an inhibitor of one or more steps in the process producing the product. An example is the release of insulin upon consumption of food. Eating releases raises blood sugar and high blood sugar releases insulin, which reduces blood sugar levels.
metabolic inhibition
Negative feedback inhibition
Feedback inhibition
feedback inhibition
The feeling of fullness and hunger are examples of the negative feedback inhibition.
feedback inhibition
feedback inhibition
feedback inhibition
feedback inhibition
Feedback inhibition works when the product of the process is an inhibitor of one or more steps in the process producing the product. An example is the release of insulin upon consumption of food. Eating releases raises blood sugar and high blood sugar releases insulin, which reduces blood sugar levels.
The steroid hormones produced by the adrenal cortex exhibit feedback inhibition on ACTH production, therefore a low concentration of corticosteroids (as seen in Addisons disease) will not exhibit this feedback inhibition. Without this inhibition, ACTH levels are not regulated and therefore rise.
metabolic inhibition
an accumulation of effectors slows the pathway.
Citrate synthase is inhibited by ATP. Obviously, the Krebs cycle produces ATP. This is the first step and one of the major regulatory steps in the pathway. If the cell has plenty of ATP, then it wouldn't need to keep making it, thus the pathway needs to be shut off. ATP inhibits the enzyme to shut off the pathway. This is an example of feedback inhibition (you can also call it negative inhibition or even product inhibition). Feedback inhibition is when the products of a certain biochemical pathway inhibit earlier enzymes, shutting down the pathway.
feedback inhibition
Feedback inhibition