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What is an ileal brake?

Updated: 11/15/2022
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12y ago

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An ileal brake is a type of long-range reflex response mediated by the action of the gut peptide hormones GLP-1 and PYY. When undigested nutrients - particularly triglycerides - reach the distal aspects of the small intestine i.e. the ileum, a feed-back mechanism is put in place to reduce the motility of the more proximal aspects of the GI tube in order to reduce the rate of movement of the substances in the gut in a bid to allow greater digestion to occur. The afferent limb is carried by Type 3 sensory fibres which signal via the prevertebral ganglia outside of the enteric nervous system.

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