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Opossums have a number of defence mechanisms.
One of their common defenses is to "play possum", i.e. their body actually enters into an involuntary comatose-like state. As many predators like the chase involved in a kill, if there is no chase, there is no thrill, and the opossum is left undisturbed until the danger passes.
Another defence is excessive drooling or dribbling, even blowing bubbles out of its nose, which makes the creature look sick and quite unappetising for a predator.
Opossums can also release a most unpleasant smelling, greenish-coloured anal fluid, which is enough to turn off any predator.
They also turn and face their predator with their mouth wide open, baring their teeth in a threatening manner. This is instinctive behaviour which young opossums do even before they have teeth.
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