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Anaplasia refers to undifferentiated cell growth in a malignant neoplasm (tumor). Lack of differentiation is considered a hallmark of malignancy. The term anaplasia literally means "to form backward." It implies dedifferentiation, or loss of structural and functional differentiation of normal cells. It is now known, however, that at least some cancers arise from stem cells in tissues; in these tumors failure of differentiation, rather than dedifferentiation of specialized cells, account for undifferentiated tumors.

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Q: What is anaplasia in describing a tumor?
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What is a change in cell structure and orientation?

A change in the structure of cells and their orientation to each other is called anaplasia.


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There is no information for the term anaplastic, however, anaplasia refers to a method of reversing the differentiation in cells that have the characteristics of malignant tumor. The term originates from the Greek word "plasis" meaning formation.


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