Arsenate acts as uncoupling agent for oxidative phosphorylation?
Yes. During glycolysis, arsenate which has a similar structure
to phosphate replaces it from glyceraldehyde-3-phosphate to form an
unstable arsenate anhydride( 1-arsenato-3-phospho-d-glycerate) that
hydrolyzes to form arsenate and 3-phosphoglycerate. In the absence
of phosphate, ATP is not formed in the reaction. ADP-arsenate is
formed from ADP and arsenate in the presence of succinate. The
formation of easily hydrolyzable ADP-arsenate complex uncouples
oxidative phosphorylation and causes arsenolysis.