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When a compound containing an asymmetric carbon atom is synthesised by ordinary laboratory methods from a symmetric compound ,the product is a racemic mixture.if ,however ,such a synthesis is carried under the asymmetric influence of a suitable optically active reagent ,only one of the optically active isomers ( or-)is formed.This process in which an asymmetric compound is synthesised from a symmetric compound to yield the ( ) isomer or (-)isomer directly is termed asymmetric synthesis.
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∙ 11y ago
Asymmetric synthesis is a method to produce chiral molecules with a specific spatial arrangement of atoms. It involves creating molecules with distinct left and right-handed forms, known as enantiomers, which have different chemical properties. This process is important in pharmaceutical and agrochemical industries to produce drugs and pesticides with desired biological activity.
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What is hydrobenzoin used for?
Hydrobenzoin is commonly used as a chemical intermediate in the synthesis of pharmaceuticals, fragrances, and other organic compounds. It can also be used as a chiral auxiliary in asymmetric synthesis to control the stereochemistry of reactions.
Who won The Nobel Prize in Chemistry in 2001?
The Nobel Prize in Chemistry in 2001 was awarded to William Knowles, Ryoji Noyori, and K. Barry Sharpless for their work in the field of asymmetric synthesis. They made significant contributions to the development of chiral catalysts used in organic synthesis, which has had a profound impact on the pharmaceutical industry.
What is chiral intermediate?
A chiral intermediate is a molecule that has an asymmetric carbon atom, resulting in non-superimposable mirror image structures known as enantiomers. These enantiomers exhibit distinct stereochemical properties and can have different biological activities or reactivities in chemical reactions. Chiral intermediates play a crucial role in asymmetric synthesis and the production of single enantiomer compounds.
How do you identify the asymmetric carbon in a molecule?
Look for a carbon atom bonded to four different groups. This configuration results in non-superimposable mirror images, making the carbon atom chiral and asymmetric.
How many asymmetric carbons are there in sugar ribose?
Ribose, CHO(CHOH)3CH2OH, is an aldopentose with three chiral carbon atoms . .............H O ...............\ // ..........H -- C -- OH .................| ..........H -- C -- OH .................| ..........H -- C -- OH .................| ..........H -- C -- OH .................| ................H
What is an asymmetric synthesis?
An asymmetric synthesis is the synthesis of a specific enantiomer of a compound, a mixture containing more of one enantioner than another.
What has the author Mark A Rizzacasa written?
Mark A. Rizzacasa has written: 'Stoichiometric asymmetric synthesis' -- subject(s): Asymmetric synthesis, Stoichiometry
What has the author Benjamin List written?
Benjamin List has written: 'Science of synthesis' -- subject(s): Catalysis, Asymmetric synthesis, Carbon compounds 'Asymmetric organocatalysis' -- subject(s): Asymmetric synthesis, Organic Chemicals, Organic compounds, Organokatalyse, Asymmetrische Synthese, Catalysis, Synthesis, Chemical synthesis, Amines
What has the author J Seyden-Penne written?
J. Seyden-Penne has written: 'Chiral auxiliaries and ligands in asymmetric synthesis' -- subject(s): Asymmetric synthesis, Chirality
What is a binaphthol?
A binaphthol is any of several phenols derived from binaphthalene, especially 1,1'-bi-2-naphthol used in asymmetric synthesis.
Asymmetric strecker synthesis for clopidogrel?
The asymmetric Strecker synthesis is a method used to prepare chiral α-amino nitriles from aldehydes and primary amines. In the case of clopidogrel, the synthesis involves the formation of the chiral α-amino nitrile, which is subsequently converted into the desired thienopyridine structure through further chemical reactions. The final steps in the synthesis involve the introduction of the clopidogrel-specific moieties to complete the synthesis of clopidogrel.
What has the author Yvonne M Malone written?
Yvonne M. Malone has written: 'The preparation and application of diphenylphosphinoferrocenyloxazoline ligands in asymmetric catalysis' -- subject(s): Catalysis, Asymmetric synthesis, Ligands
What has the author John P Cahill written?
John P. Cahill has written: 'The Preparation and Application of Diphenylphosphinopyrrolidine Ligands in Asymmetric Catalysis' -- subject(s): Chirolity, Asymmetric synthesis, Ligands
What is hydrobenzoin used for?
Hydrobenzoin is commonly used as a chemical intermediate in the synthesis of pharmaceuticals, fragrances, and other organic compounds. It can also be used as a chiral auxiliary in asymmetric synthesis to control the stereochemistry of reactions.
What has the author Michael Daniel Fryzuk written?
Michael Daniel Fryzuk has written: 'Asymmetric synthesis' -- subject(s): Catalysts, Hydrogenation
What has the author Guo-Qiang Lin written?
Guo-Qiang Lin has written: 'Chiral drugs' -- subject(s): Pharmaceutical Preparations, Methods, Structure-Activity Relationship, Drug development, Chiral drugs, Drug Discovery, Chemistry, Structure-activity relationships (Biochemistry) 'Principles and applications of asymmetric synthesis' -- subject(s): Asymmetric synthesis
What has the author Jeffrey Ronald Engebrecht written?
Jeffrey Ronald Engebrecht has written: 'Chiral synthesis of alcohols via asymmetric epoxidation' -- subject(s): Alcohols, Analysis
