Bronchodilation.
Beta-2
Bronchodilation
CPT Code 94060 : Bronchodilation responsiveness, spirometry as in 94010, pre- and post-bronchodilator administration
bronchiectasis is abnormal dilation of the airways; bronchodilation is therapeutic or natural dilation of the airways.
Aminophylline is a bronchodilator. Its most common use is in the treatment of bronchial asthma. Aminophylline causes bronchodilation, diuresis, central nervous system.
coz it works on alpha 1 adrenergic receptors in small blood vessels causing vasoconstriction and hence increase blood pressure (contrary to its action on skeletal muscles) it is also working on B2 adrenergic receptors causing bronchodilation
The best thing to use is an inhaler, but if you don't have one, try drinking hot coffee or taking a hot shower. What ever you do, be as calm as you can in this situation, as stress or anxiety will only make the asthma attack worse. Caffiene can sometimes aid bronchodilation as well as the heated humidity that you breathe in during a hot shower. If the symptoms are bad, don't wait. Go to the emergency room or doctors office right away.
Adrenergic drugs (specifically Beta 2 Agonists) are useful in treating a severe asmatic attack because they promote bronchodilation of the smooth muscle of the lung. They also suppress histamine release in the lung and increase ciliary motility. Most of these drugs are administered orally or as inhalers. Most inhaled Beta2 Agonist drugs are short acting but offer immediate relief. The oral medications are longer acting but have a delayed onset.
parasympathetic system (PSNS) will a)vasoconstrict the lumen of airway by contracting smooth muscle cells along the conducting passage via M3 Receptor, b)increase mucus secretion via M3 Overall it'll interfere with normal breathing pattern and obstruct normal breathing.
Most bronchodilators, such as albuterol (aka salbutamol in Europe), are modifications of adrenaline (epinephrine). There are several different types of adrenaline receptors in the body and the medications bind better to the type that opens up the lungs than to the type that speeds up the heart. That, and the fact that you deliver more drug to the lungs than the heart by inhaling them, means that the effect of the medication is much greater in the lung (bronchodilation) than in the heart (fast heart rates - tachycardia). This is not perfect. Some is absorbed into the blood, especially if the inhaler is used a lot, and so gets to the heart and makes it go fast.
Bronchoconstriction is the constriction of the airways in the lungs due to the tightening of surrounding smooth muscle, with consequent coughing, wheezing, and shortness of breath. Bronchoconstriction is due to an activation of the parasympathetic nervous system. Postganglionic parasympathetic fibers will release acetylcholine next to the Reissessen muscle, a smooth muscle layer surrounding the bronchi. These smooth muscle cells have M3 type muscarinic receptors on their membrane. The activation of these receptors by ACH will activate an intracellular Gq protein, that in turn will activate the PLC pathway, that will end in an increase of intracellular calcium concentrations and therefore contraction of the smooth muscle cell. The muscle contraction will cause the diameter of the bronchus to decrease, therefore increasing its resistance. Air flow in air passages can get restricted due to 3 factors: - a spasmodic state of the smooth muscles in bronchi and bronchioles - an inflammation of the airways - excessive production of mucus due to an allergic reaction or irritation caused by mechanical friction of air (due to shear stress), overcooling or drying of airways. Bronchoconstriction is common in people with respiratory problems, such as asthma, COPD, and cystic fibrosis. The condition has a number of causes, the most common being emphysema as well as asthma. Exercise and allergies can bring on the symptoms in an otherwise asymptomatic individual.