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AnswerCholesterol Production
  • The production pathway includes the liver.
  • Inhibition of cholesterol production reduces cholesterol synthesis in the liver and upregulates LDL-C receptors to increase clearance of LDL-C from the blood.
Intestinal Absorption
  • The absorption pathway includes the small intestine.
  • Inhibition of intestinal cholesterol absorption leads to a reduction in hepatic cholesterol stores, increasing clearance of cholesterol from the blood.
Reference: 1.

Shepherd J. The role of the exogenous pathway in hypercholesterolaemia. Eur Heart J Suppl. 2001;3(suppl E):E2–E5.

Cholesterol Production
  • The production pathway includes the liver.
  • Inhibition of cholesterol production reduces cholesterol synthesis in the liver and upregulates LDL-C receptors to increase clearance of LDL-C from the blood.
Intestinal Absorption
  • The absorption pathway includes the small intestine.
  • Inhibition of intestinal cholesterol absorption leads to a reduction in hepatic cholesterol stores, increasing clearance of cholesterol from the blood.
Reference: 1.

Shepherd J. The role of the exogenous pathway in hypercholesterolaemia. Eur Heart J Suppl. 2001;3(suppl E):E2–E5.

Joymaker RN

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