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What is frame shift?

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Anonymous

7y ago
Updated: 8/2/2021

A frame shift mutation is one in which the "reading frame" for protein synthesis is altered.

Starting from the DNA, you have either the insertion or deletion of one or more base pairs (but not in a multiple of three). For example, onebase pairmay be inserted into the coding portion of a gene. This is transcribed into mRNA then taken to the ribosome to be "read" (translated) by the tRNA. However, tRNA has three bases on the end of it, which correspond to a specific amino acid. By adding one base into the sequence, you "shift" the reading frame by one base pair and completely change the entire remaining amino acid sequence.

Note that if you were to add or subtract three (or a multiple of three) base pairs, you would not shift the frame - you would add or subtract amino acids, but the remaining ones would be the same as the original sequence.

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Wiley Waelchi

Lvl 10
4y ago

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Related Questions

How many nucleotides would cause a frame shift mutation?

Adding or subtracting just one nucleotide would cause a frame shift mutation.


How are point mutations and frame shift mutations different?

Point Mutations always result in [causing] a frame-shift mutation so they are the same.


Was the sequence a result of point or frame shift mutation?

No


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Which of the following is a point mutation that does not produce a frame shift?

A point mutation that does not produce a frame shift is when one single base is replaced by a different base. This changes the DNA sequence, but does not cause a frame shift because it is a switch not an addition or subtraction of a base.


Why is point mutation dangerous?

A frame shift mutation destroys the correct sequence of amino acids from the point of the mutation. The protein produced by a frame shift mutation would more than likely be nonfunctional.


Does frame shift mutation affect hemophilia?

Frame shift mutations that occur on the X chromosome and within the potion of code that controls the formation of clotting factors can cause hemophilia. Frame shift mutations are only one of many types of mutations that can cause the disorder. For hemophilia it's not so much the type of mutation but the location of the mutation within the genetic code.


What is the type of mutation that shifts the reading frame of the genetic message by inserting or deleting a nucleotide?

A frame-shift mutation.


How can i describe the effects of a frame-shift mutation?

A frame-shift mutation occurs when nucleotides are added or deleted from a DNA sequence, altering the reading frame of the genetic code. This shift can lead to the production of an entirely different and often nonfunctional protein, as the sequence of amino acids is changed downstream of the mutation. Consequently, frame-shift mutations can result in significant biological consequences, including diseases or developmental disorders, depending on the protein affected. Overall, they disrupt normal cellular function by producing abnormal proteins or prematurely truncating them.


What are two types of frame shift mutations?

"I believe there is insertion and deletion, (one kind), and substitutions. (the second kind)" This answer is incorrect, the two types of frameshift mutation are insertion and deletion, these both alter the translation reading frame. A substitution point mutation in DNA is referred to as a single-nucleotide polymorphism and does not result in any change to the translational reading frame. insections and deletions are two types of frameshift mutations


When does a reading frame shift occur?

A reading frame shift occurs when nucleotides are inserted or deleted from a DNA or mRNA sequence, causing a shift in the way the sequence is interpreted by the ribosome during translation. This can result in a completely different amino acid sequence being produced, leading to a non-functional or altered protein.