Knoxville, TN
Midland is the halfway point between Lexington South Carolina and Bennettsville.
The halfway point between South Carolina (SC) and Illinois (IL) is Renfro Valley, Kentucky.
The closest town to the midpoint is Kuttawa, Kentucky.
The halfway point between Bartow, Florida and Greenville, South Carolina falls in Townsend, Georgia.
The halfway point from Goose Creek, South Carolina and Elizabethtown, Kentucky is in Cosby, Tennessee.
I'm not an expert (because I'm from London, England) but I would probably say Lexington, Kentucky.
Yemassee, SC
Tallahoma, Mississippi is halfway between Santa Fe & Pendleton
The halfway point between Knoxville, Tennessee, and Covington, Kentucky, is just south of Berea, Kentucky, on I-75, between Berea and Mt. Vernon.
The halfway point is the North Carolina/ South Carolina border where that annoying South of the Border hotel is. When I make that trip, I drive one more exit south, to Florence, South Carolina.
Daniels, WV
Sand